Meta-analysis for Discovering Rare-Variant Associations: Statistical Methods and Software Programs
نویسندگان
چکیده
منابع مشابه
Meta-analysis of gene-level associations for rare variants based on single-variant statistics.
Meta-analysis of genome-wide association studies (GWASs) has led to the discoveries of many common variants associated with complex human diseases. There is a growing recognition that identifying "causal" rare variants also requires large-scale meta-analysis. The fact that association tests with rare variants are performed at the gene level rather than at the variant level poses unprecedented c...
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Genome-wide assocation studies have often been carried out by meta-analysis rather than by pooling individual-level data. For one-dimensional parameter estimates and the corresponding tests of association these meta-analyses lead to essentially no loss of information relative to pooling individual data. The situation is different for multiparameter tests, such as the omnidirectional rare-varian...
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ژورنال
عنوان ژورنال: The American Journal of Human Genetics
سال: 2015
ISSN: 0002-9297
DOI: 10.1016/j.ajhg.2015.05.001